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Methods: In a double-blinded, placebo-controlled, three crossover design, 17 healthy volunteers were randomized to oral coenzyme Q10 (100 or 300 mg/d) or placebo administration for 8 days. As a fatigue-inducing physical task, subjects performed workload trials on a bicycle ergometer at fixed workloads twice for 2 hours and then rested for 4 hours. During the physical tasks, subjects performed non-workload trials with maximum velocity for 10 s at 30 min (30-min trial) after the start of physical tasks and 30 min before the end of the tasks (210-min trial).

Results:

Conclusion: Oral administration of Coenzyme Q10 improved subjective fatigue sensation and physical performance during fatigue-inducing workload trials and might prevent unfavorable conditions as a result of physical fatigue.

Source: Nutrition. 2008 Feb 11 [E-pub ahead of print] PMID: 18272335, by Mizuno K, Tanaka M, Nozaki S, Mizuma H, Ataka S, Tahara T, Sugino T, Shirai T, Kajimoto Y, Kuratsune H, Kajimoto O, Watanabe Y. Department of Physiology, Osaka City University Graduate School of Medicine, Osaka, Japan; 21st Century COE Program “Base to Overcome Fatigue”, Japanese Government, Osaka, Japan. [E-mail: mizuno@med.osaka-cu.ac.jp]