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Study Title: Effectiveness of Methylphenidate in Improving Cognition and Function in Older Adults with Depression. ClinicalTrials.gov ID NCT00602290

Objective: To measure speed of recovery and extent of cognitive (reasoning & memory) and functional improvement in depressed subjects treated initially with the antidepressant drug methylphenidate – both alone and used to augment the commonly used antidepressant citalopram.

Additionally, genetic profiling will be done to identify any differences in treatment response associated with dopamine- and serotonin-related genes.

Methylphenidate has long been used in the medically ill and older adults “to provide rapid improvement in depression, apathy, and fatigue.” But its ability to support improved cognitive function and functional rehabilitation in depressed patients – alone or in combination with other drugs - has not been evaluated. And currently many mature adults treated for depression are “left with significant residual symptoms" in these respects.

For more information: To read a detailed description of this trial, review the inclusion and exclusion criteria, and for contact information, go to the ClinicalTrials.gov description of Trial NCT00602290.