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Bickford PC, Tan J, Shytle RD, Sanberg CD, El-Badri N, Sanberg PR.

Center of Excellence for Aging and Brain Repair, University of South Florida College of Medicine, Tampa, FL 33612., James A. Haley Veterans Administration Hospital, Tampa, FL 33612.

A viable alternative to stem cell transplantation is to design approaches that stimulate endogenous stem cells to promote healing and regenerative medicine. Many natural compounds have been shown to promote healing; however, the effects of these compounds on stem cells have not been investigated. We report here the effects of several natural compounds on the proliferation of human bone marrow and human CD34(+) and CD133(+) cells. A dose-related effect of blueberry, green tea, catechin, carnosine, and vitamin D(3) was observed on proliferation with human bone marrow as compared with human granulocyte-macrophage colony-stimulating factor (hGM-CSF). We further show that combinations of nutrients produce a synergistic effect to promote proliferation of human hematopoietic progenitors. This demonstrates that nutrients can act to promote healing via an interaction with stem cell populations.

PMID: 16522169 [PubMed - in process]